There is no standard potency of a drop of liquid LSD. A single drop typically ranges from 75 ugs to 300 ugs, but could be lower or higher.
The manufacturer of liquid LSD will determine the potency of each drop, by controlling the ratio of crystalline LSD to the alcohol/water solvent used. For example, if a manufacturer wants a 125 ug dose from a single drop and one assumes a standard dropper bottle dispenses 0.05 ml per drop of LSD (this is a commonly used assumption), then one must mix a concentration of 125 ug of LSD per 0.05 ml of final solution.
If preparing 10,000 drops, one would need 1,250,000 ug of LSD (125 ug x 10,000 units = 1,250,000 ug, or 1.25 grams). One would also need enough solvent to produce 500 ml of final liquid. In this final solution, each 0.05 ml drop of solution contains 125 ug of LSD. (As an aside, the density of LSD is 1.2±0.1 g cm−31.2±0.1 g cm−3, and therefore 1.25 grams of LSD is around 58 ml. So one would use 442 ml of solvent for 1.25 g of LSD to produce 500 ml of LSD solution).
Many people who use LSD regularly prefer liquid acid to all other forms, because when properly stored, it can last for many years, absorbs quickly and is easy to effectively split.
Most people prefer to have some food in their stomach, but only a light snack. It is important to avoid drinking tap water, as the chlorine and certain other chemicals used in municipal water supply will destroy LSD on contact. Even bottled water may contain these chemicals, so avoiding drinking water for an hour or so before tripping may be advised.
The simplest way to take liquid LSD is to apply a drop to a sugar cube or on a spoon, place in one’s mouth and keep it there as long as possible to allow it to absorb through the skin. LSD is rapidly absorbed under the tongue (sublingual), and sublingual absorption eliminates any concern around having food in the stomach that might slow absorption. Or worse, having chlorinated water one’s stomach, destroying the LSD.
One should avoid putting liquid LSD directly from the bottle to your mouth to avoid ending up with two drops or zero drops, as it can be surprisingly challenging to see drops. Dispensing onto a medium such as a sugar cube or onto a spoon reduces error. We always have two people watch when we distribute a dose, especially if re-dosing while intoxicated.
Avoid putting doses on anything too small, or medium that has no absorption, as in either case the drop may run off.
When distributing liquid LSD it is important to hold the bottle directly vertical, and to slowly and gently squeeze the bottle to get a uniform drop.